In 2005, Stanford epidemiologist John Ioannidis published the provocatively titled paper “Why most published research findings are false” (Ioannidis, PLoS Med 2005, 2:e12), that has since become a foundational piece of metascience. Among other things, he stated: The smaller the study sample conducted in a scientific field, the less likely the research findings are to…
The Reproducibility Crisis in Medicine
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